Efficacy and quality of life (QoL) of cabazitaxel/prednisone (Cbz) in Canadian metastatic castration resistant prostate cancer (mCRPC) patients (pts) with or without prior abiraterone acetate (Abi).
Bibliographic record
Abstract
5062^ Background: In the TROPIC study, Cbz was shown to improve overall survival in mCRPC pts post-docetaxel, however none of these pts had prior exposure to Abi. To better understand the impact of prior Abi treatment on Cbz efficacy and QoL, we evaluated Canadian pts enrolled in the International Phase IIIb/IV single arm Cbz study. Methods: In total 61 pts were enrolled from 9 centers (May 2011 to February 2012). Cbz efficacy (PSA Response Rate (RR, decline ≥50%)) and impact on QoL were analyzed as a function of prior Abi use. Results: Baseline and disease characteristics were similar between NoPriorAbi (n=35, 57%) and PriorAbi (n=26, 43%) groups, except for age and time between last docetaxel dose and progression (Table). Pts received a median of 9 cycles of prior docetaxel. 92% of pts were ECOG 0/1, with 88% having bone metastases and 25% visceral metastases. 31% of pts received prophylactic G-CSF. Median number of Cbz cycles received was similar between groups (NoPriorAbi= 6, PriorAbi= 7) as were PSA RR (NoPriorAbi= 42.4%, PriorAbi= 47.6%, p=0.78). QoL and pain were improved in Cbz pts with no significant difference observed based on prior Abi use (Table). Overall, treatment discontinuation was mainly due to progression (45.9%) and adverse events (32.8%). Most frequent grade 3/4 toxicities were anemia and fatigue (9.8%), with diarrhea, neutropenia and febrile neutropenia each observed in 8.2% of pts. Conclusions: Cbz efficacy and impact on QoL were not affected by prior Abi use. In routine clinical practice, toxicity rates observed were similar to the TROPIC study. Clinical trial information: NCT01254279. Variable Unit Total No Prior Abi Prior Abi P Median age Yrs 65 64 69 0.02 Time between last docetaxel dose and progression <0 mos 11.7 17.1 4.0 0.05 0-3 23.3 28.6 16.0 3-6 18.3 14.3 24.0 ≥6 46.7 40.0 56.0 Pts with ≥10 cycles of Cbz % 26.7 28.6 24.0 0.70 FACT-P ≥16 points ǂ % 14.8 12.1 19.1 0.70 FACT-P ≥6 points ǂ % 44.4 39.4 52.4 0.41 PCS subscale ≥2 points ǂ % 53.7 51.52 57.14 0.78 PCS pain subscale ≥2 points ǂ % 27.8 24.24 33.33 0.54 Pain response Rate * ǂ % 20.7 15.00 33.33 0.34 * as defined in TROPIC (de Bono 2010). ǂ Minimal clinically important difference observed on 2 consecutive cycles.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".