Molecular characteristics of VP2 gene from wild-type infectious bursal disease viruses (IBDVs) in Saudi Arabia
Bibliographic record
Abstract
Infectious bursal disease (IBD) is caused by a virus related to the family Birnaviridae. The virus is a worldwide pathogen and causes immunosuppression and great losses in broiler flocks. In this study, molecular characterization of two Saudi Arabian IBDVs (IBD01/14/SA and IBD02/14/SA) was carried out by reverse transcriptase polymerase chain reaction (RT-PCR) and partial sequence of hypervariable region of VP2 gene. Nucleotide sequences of 740-bp PCR product of the Saudi Arabian isolates were compared with the corresponding nucleotide sequence of 56 reported IBDVs representing different pathotypes from different continents. Phylogenetic analysis showed that the Saudi Arabian isolates were split from the tree to form a distinguished cluster with the Canadian IBDVs and 586/USA field viruses. Deduced amino sequences from both strains were found to share the amino acid substitutions of the standard very virulent (vv) strains. The Saudi Arabian strains showed unique amino acid substitutions 254N and 359K and exhibited a modified antigenic profile. The deduced amino acid sequence and antigenic profile of both wild-type Saudi Arabian strains showed high similarity to the IBDI+ vaccines; hence, the Saudi Arabian strains might be more useful for protecting chickens against overt clinical signs and mortalities.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".