Changes in expression of the<scp>CD</scp>200 tolerance‐signaling molecule and its receptor (<scp>CD</scp>200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis
Bibliographic record
Abstract
Problem Expression of CD 200 at the feto‐maternal interface is associated with successful murine and human pregnancy. CD 200 binding to CD 200 receptors on lymphomyeloid cells suppresses inflammation and induces Tregs. CD 200 receptors are also expressed on mouse and human placental trophoblast cells. What is the expression of CD 200 and CD 200R in human missed abortions which have preserved Treg levels and in chronic histiocytic intervillositis ( CHI ) where maternal inflammatory cells cause IUGR ? Methods Immunohistiochemistry for CD 200, CD 200R, and Ki67 using human placental sections from missed abortions, term placenta, and CHI . PCR testing was done for trisomy in missed abortion. Results CD 200 and CD 200R were expressed by human villus trophoblasts from 2 weeks post‐implantation to term. Cytotrophoblast proliferation (Ki‐67 + count) decreased at term. In first trimester missed abortion cases, CD 200> CD 200R villus trophoblasts accompanied missed abortion of non‐trisomic male fetuses. CD 200 and Ki67 + trophoblast proliferation was preserved in CHI with maternal inflammatory cell infiltration but CD 200R was greatly decreased. Conclusion Residual CD 200 activity may prevent completion of abortions via induction of Treg cells. In CHI , infiltrating maternal effector T cells may block Treg induction. An autocrine role for CD 200‐ CD 200R interaction versus inhibition of soluble CD 200 by soluble CD 200R is discussed.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".