Changes in expression of the<scp>CD</scp>200 tolerance‐signaling molecule and its receptor (<scp>CD</scp>200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis
Bibliographic record
Abstract
Problem Expression ofCD200 at the feto‐maternal interface is associated with successful murine and human pregnancy.CD200 binding toCD200 receptors on lymphomyeloid cells suppresses inflammation and induces Tregs.CD200 receptors are also expressed on mouse and human placental trophoblast cells. What is the expression ofCD200 andCD200R in human missed abortions which have preserved Treg levels and in chronic histiocytic intervillositis (CHI) where maternal inflammatory cells causeIUGR? Methods Immunohistiochemistry forCD200,CD200R, and Ki67 using human placental sections from missed abortions, term placenta, andCHI.PCRtesting was done for trisomy in missed abortion. Results CD200 andCD200R were expressed by human villus trophoblasts from 2 weeks post‐implantation to term. Cytotrophoblast proliferation (Ki‐67+count) decreased at term. In first trimester missed abortion cases,CD200>CD200R villus trophoblasts accompanied missed abortion of non‐trisomic male fetuses.CD200 and Ki67+trophoblast proliferation was preserved inCHIwith maternal inflammatory cell infiltration butCD200R was greatly decreased. Conclusion ResidualCD200 activity may prevent completion of abortions via induction of Treg cells. InCHI, infiltrating maternal effector T cells may block Treg induction. An autocrine role forCD200‐CD200R interaction versus inhibition of solubleCD200 by solubleCD200R is discussed.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".