Unsymmetrical Iron P‐NH‐P′ Catalysts for the Asymmetric Pressure Hydrogenation of Aryl Ketones
Bibliographic record
Abstract
Abstract The reductive amination of α‐dialkylphosphine acetaldehydes with enantiopure β‐aminophosphines is a new, versatile route to unsymmetrical tridentate (pincer) ligands P‐NH‐P′. Four new ligands PR 2 CH 2 CH 2 NHCHR′CHR′′PPh 2 (R= i Pr, Cy, R′=Ph, CH(CH 3 ) 2 , R′′=Ph, H) prepared in this way are used to make the iron(II) complexes mer ‐FeCl 2 (CO)(P‐NH‐P′) and mer ‐FeCl(H)(CO)(P‐NH‐P′). The hydride complex with the rigid ligand with R′=R′′=Ph is an efficient and highly enantioselective homogeneous asymmetric pressure hydrogenation (APH) catalyst. Prochiral aryl ketones are reduced under mild conditions (THF, 0.1 mol % catalyst, 1 mol % KO t Bu, 5–10 bar, 50 °C) to the ( S )‐alcohols, usually in enantiomeric excess ( ee ) greater than 90 %. DFT calculations provided transition‐state structures for the enantiodetermining hydride‐transfer step.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".