Long-chain omega-3 fatty acid and fish intake after colon cancer diagnosis and disease-free, recurrence-free, and overall survival in CALGB 89803 (Alliance).
Bibliographic record
Abstract
585 Background: Long-chain omega-3 fatty acids (LCN-3 FA) may prevent colon cancer (CC) progression, but data in humans are lacking. We hypothesized that LCN-3 FA and dark meat fish intake after CC diagnosis would be associated with longer disease-free survival (DFS), particularly among patients (pts) whose tumors expressed COX2. Methods: We conducted a prospective study among 1011 stage III CC pts enrolled in an adjuvant chemotherapy trial in 1999-2001. Intakes of dark meat fish; canned tuna; breaded fish; shrimp, lobster, scallops, clams; other fish; and fish oil supplements were assessed via food frequency questionnaire during and 6 months (mo) after therapy. Less than 5% of pts reported fish oil supplements. We estimated hazard ratios (HR) and 95% confidence intervals (CI) for disease-free, recurrence-free (RFS), and overall (OS) survival, adjusting for clinical, sociodemographic, and lifestyle factors. In a subset of 510 pts, we examined whether tumor COX2 expression modified the association between LCN-3 FA intake and DFS. Results: We observed 343 CC recurrences and 305 deaths (7 y median follow-up). Higher LCN-3 FA intake after CC diagnosis was associated with 28% improved DFS [HR highest (Q4) vs. lowest (Q1) quartile: 0.72 (0.54, 0.97); p: 0.03]. The association was driven by CC recurrence [RFS - HR Q4 vs. Q1: 0.68 (0.50, 0.94); p: 0.01; OS - HR Q4 vs. Q1: 0.79 (0.56, 1.13); p: 0.17]. Among pts with moderate/high COX2 expression tumors, LCN-3 FA intake was associated with 80% improved DFS [HR Q4 vs. Q1: 0.2 (0.06-0.76); p: 0.006]; there was no association among pts with absent/low COX2 expression ( p-interaction: 0.13). When we examined dietary sources of LCN-3 FA, pts who consumed dark meat fish ≥ 2 times/mo vs. none had longer DFS [HR: 0.64 (0.48, 0.86); p: 0.007), RFS [HR: 0.61 (0.44, 0.83); p: 0.005], and OS [HR: 0.68 (0.48, 0.97); p: 0.05]. No other fish or seafood after CC diagnosis was associated with DFS, RFS, or OS. Conclusions: LCN-3 FA and dark meat fish intake after CC diagnosis may be associated with improved DFS, especially among pts with high COX2 expression tumors. Support: K07CA197077, U10CA180821, U10CA180882. ClinicalTrials.gov: NCT00003835.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".