Asia Pacific Stroke Conference 2015 Abstracts of the Annual Conference of the Asia Pacific Stroke Organization (APSO) Kuala Lumpur, Malaysia, October 2-4, 2015: Abstracts
Bibliographic record
Abstract
Background: Clopidogrel napadisilate has better clopidogrel stability than clopidogrel bisulfate. Our trial’s objective was \nto compare the efficacy and safety of clopidogrel napadisilate with clopidogrel bisulfate in participants with ischemic stroke. \nMethods: The study was a phase 4, 4-week, randomized, parallel-group, non-inferiority trial. Patients are randomized to receive either clopidogrel napadisilate 75 mg or clopidogrel bisulfate 75 mg. The primary study endpoint was change from baseline in P2Y12 percent inhibition at week 4. The primary analysis was conducted in the per-protocol population. Noninferiority was confirmed if the lower limit of the 95% confidence interval (CI) of the treatment difference was more than or equal to –9.0% points. The secondary endpoint was change in P2Y12 reactivity units (PRU). At a final visit, all adverse events were recorded. Results: Sixty-one participants were randomly assigned clopidogrel napadisilate and 60 were randomly assigned clopidogrel bisulfate. Thirty-nine participants in the clopidogrel napadisilate group and 39 in the clopidogrel bisulfate group were analyzed for the primary endpoint. At 4 weeks, mean percent inhibition had increased in both treatment groups. The estimated mean change from baseline was 22.3% with clopidogrel napadisilate and 21.4% \nwith clopidogrel bisulfate; the estimated treatment difference of 0.9% (95% CI, –8.6 to 10.4) confirmed the non-inferiority of clopidogrel napadisilate to clopidogrel bisulfate. The mean reduction in PRU and rates of adverse events were not significantly different between treatments. \nConclusion: Clopidogrel napadisilate was noninferior to clopidogrel bisulfate as assessed by change in platelet inhibition. \nRates of adverse events were similar between the two groups. Therefore, clopidogrel napadisilate can be a suitable alternative to clopidogrel bisulfate in ischemic stroke patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.003 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.129 | 0.052 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".