The Adipokine Omentin in Late-stage Rheumatoid Arthritis and Endstage Osteoarthritis
Bibliographic record
Abstract
To the Editor: In the past several years, adipokines have gained a lot of attention in the field of rheumatic diseases1. Rheumatoid arthritis (RA), for example, is associated with an altered production of adipokines1, and there is some evidence of involvement of adipokines in the pathophysiology of RA as suggested by in vitro 1 and in vivo data2,3. The term “adipokines” was originally used to describe cytokine-like factors secreted by adipose tissue, but it turned out that many adipokines are also produced at other sites including the joints1,4,5, where they might have an influence on effector cells of RA or osteoarthritis (OA) pathophysiology. As an adipokine, omentin was first found in omental adipose tissue from patients with Crohn disease6. Before this, it was identified as a secretory glycoprotein able to bind to galactofuranosyl residue on various microorganisms, suggesting a function in immune recognition of certain pathogens. It has also been described as a lactoferrin-binding protein with lactoferrin being a protein with multiple immunological functions. Omentin is highly abundant in human plasma6. It displayed antiinflammatory and antiatherogenic properties in obese patients7 … Address correspondence to Dr. K.W. Frommer, Department of Internal Medicine and Rheumatology, University of Giessen, Kerckhoff Clinic, Benekestrasse 2-8, D-61231 Bad Nauheim, Germany. E-mail: k.frommer{at}kerckhoff-klinik.de
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.004 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".