Heritability of Heart Rate upon Stimulation in Members of Families with History of Hypertension
Bibliographic record
Abstract
P139 Objectives:Heart rate (HR) is an independant risk factor for cardiovascular disease and believed to be in part genetically determined. We have studied the heritability of HR in members of large families with history of hypertension (HT). In addition, candidate genes involved in cardiovascular regulation were tested. Methodology:Under study, families of the Saguenay-Lac St-Jean of the province of Quebec showed a higher prevalence of HT in all age groups than the national and provincial population and high degree of kinship. Using impedance plethysmography HR was recorded during posture and mental stress tests. DNA extracted from blood leucocytes was analysed by PCR for the ACE and TNF-α genes. Heritability and linkage were analysed with the FCOR and SIBPAL programs of the SAGE package. Results: HR changed significantly from the resting supine position to standing, sitting, 2 min. and 4 min. into the math test and returned to baseline after 10 min of rest. Heritability (h 2 ) estimates are shown in the table below. Indexes of h 2 were significant during math test and the recovery period (*:p
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".