Memory ILC2s and type 2 lung inflammation
Bibliographic record
Abstract
Abstract Group 2 innate lymphoid cells (ILC2s) are critical mediators of allergic lung inflammation. Upon protease allergen encounter, epithelial-derived IL-33 activates ILC2s to produce large amounts of type 2 inflammatory cytokines. ILC2-derived cytokines induce T helper 2 (Th2) cell-independent allergic lung inflammation. Upon activation a subset of lung ILC2s becomes long-lived memory cells. Memory ILC2s are more sensitive and respond stronger to unrelated allergen encounters. Gene expression analysis and transfer experiments show that the high responsiveness is due to intrinsic changes in memory ILC2s. Indeed, memory ILC2s not only respond to IL-33 but also become responsive to the alarmin IL-25. Finally, memory ILC2s promote early Th2 differentiation in the draining lymph node, which leads to a stronger memory T cell response. On the other hand, the generation and maintenance of memory ILC2s is T-cell independent. Understanding the regulation of memory ILC2s may lead to the development of novel therapies for allergic diseases.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".