0521 IMPACT OF MASK TYPE ON CONTINUOUS POSITIVE AIRWAY PRESSURE EFFICACY AND COMPLIANCE: A META-ANALYSIS
Bibliographic record
Abstract
Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnea (OSA). The impact of the mask type on the efficacy and acceptance of CPAP is inconclusive. The present study aimed to compare the effects and compliance of oronasal and nasal mask by the meta-analysis of the existing trials. Studies were retrieved from PubMed, EMBASE, and CENTRAL up to August 2016. The literature was reviewed by two independent authors. The mean difference of residual apnea-hypopnea index (AHI), therapeutic pressure, usage hour, and preference between oronasal and nasal mask was quantified. The pooled effect was analyzed with random-effect generic inverse variance and the heterogeneity was assessed with I2. From 6070 articles, 13 studies comprising 4000 subjects were included for the meta-analysis. The number of recruited subjects was different and the recruited trials were heterogeneous for all four outcomes. The 寫Newcastle-Ottawa scale showed that two studies (120 subjects) enrolling participants inadequately response to oronasal CPAP were biased. Compared to nasal masks, the oronasal masks had higher residual AHI for 5.5/hour (95% CI 2.3–8.8, p<0.001, I2 94%, 676 subjects), higher therapeutic pressure for 1 cmH2O (0–2.1, p=0.05, I2 76%, 534 subjects), and shorter usage per night for 0.8 hour (-1.06 - -0.54, p<0.001, I2 25%, 1364 subjects), and less preferred (odds ratio 0.05, 95% CI 0–0.6, p=0.02, 153 subjects). The subgroup analysis of 11 unbiased trials (3880 subjects) gave the same results for all four outcomes. Subgroup analysis of 5 randomized control trials (RCT) (176 subjects) had similar results except that therapeutic pressure was similar between two masks (p=0.97). The present studies showed that oronasal masks were associated with higher residual AHI, higher therapeutic pressure, shorter usage, and less preference compared to nasal masks. This study was supported by National Taiwan University (NTU) Hospital (105-S2998), Ministry of Science and Technology (103-2314-B-002-139-MY3), and NTU (NTU-ERP-105R8951-1).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".