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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Mariaelisa Graff, Robert A. Scott, Anne E. Justice, Kristin L. Young, Mary F. Feitosa, Llilda Barata, Thomas W. Winkler, Audrey Y. Chu, Anubha Mahajan, David Hadley, Luting Xue, Tsegaselassie Workalemahu, Nancy L. Heard‐Costa, Marcel den Hoed, Tarunveer S. Ahluwalia, Qibin Qi, Julius S. Ngwa, Frida Renström, Lydia Quaye, John D. Eicher, James E. Hayes, Marilyn C. Cornelis, Zoltán Kutalik, Elise Lim, Jian’an Luan, Jennifer E. Huffman, Weihua Zhang, Wei Zhao, Paula J. Griffin, Toomas Haller, Shafqat Ahmad, Pedro Marques‐Vidal, Stephanie A. Bien, Loïc Yengo, Alexander Teumer, Albert V. Smith, Meena Kumari, Marie Neergaard Harder, Johanne Marie Justesen, Marcus E. Kleber, Mette Hollensted, Kurt Lohman, Natalia V. Rivera, John B. Whitfield, Wei Zhao, Heather M. Stringham, Leo‐Pekka Lyytikäinen, Charlotte Huppertz, Gonneke Willemsen, Wouter J. Peyrot, Ying Wu, Kati Kristiansson, Ayşe Demirkan, Myriam Fornage, Maija Hassinen, Lawrence F. Bielak, Gemma Cadby, Toshiko Tanaka, Reedik Mägi, Peter J. van der Most, Anne Jackson, Jennifer L. Bragg‐Gresham, Véronique Vitart, Jonathan Marten, Pau Navarro, Claire Bellis, Dorota Pasko, Åsa Johansson, Søren Snitker, Yu‐Ching Cheng, Joel Eriksson, Unhee Lim, Mette Aadahl, Linda S. Adair, Najaf Amin, Beverley Balkau, Juha Auvinen, John Beilby, Richard N. Bergman, Sven Bergmann, Alain G. Bertoni, John Blangero, Amélie Bonnefond, Lori L. Bonnycastle, Judith B. Borja, Søren Brage, Fabio Busonero, Steven Buyske, Harry Campbell, Peter S. Chines, Francis S. Collins, Tanguy Corre, George Davey Smith, Graciela E. Delgado, Nicole Dueker, Marcus Dörr, Tapani Ebeling, Guðný Eiríksdóttir, Tõnu Esko, Jessica D. Faul, Mao Fu, Kristine Færch, Christian Gieger, Sven Gläser, Jian Gong, Penny Gordon‐Larsen, Harald Grallert, Tanja B. Grammer, Niels Grarup, Gerard van Grootheest, Kennet Harald, Nicholas D. Hastie, Aki S. Havulinna, Dena Hernández, Lucia A. Hindorff, Lynne J. Hocking, Oddgeir L. Holmens, Christina Holzapfel, Jouke‐Jan Hottenga, Jie Huang, Tao Huang, Jennie Hui, Cornelia Huth, Nina Hutri‐Kähönen, John‐Olov Jansson, Min A. Jhun, Markus Juonala, Leena Kinnunen, Heikki A. Koistinen, Ivana Kolčić, Pirjo Komulainen, Johanna Kuusisto, Kirsti Kvaløy, Mika Kähönen, Timo A. Lakka, Lenore J. Launer, Benjamin Lehne, Cecilia M. Lindgren, Mattias Lorentzon, Robert Luben, Michel Marre, Yuri Milaneschi, Keri L. Monda, Grant W. Montgomery, Marleen H. M. de Moor, Antonella Mulas, Martina Müller‐Nurasyid, Arthur W. Musk, Reija Männikkö, Satu Männistö, Narisu Narisu, Matthias Nauck, Jennifer A. Nettleton, Ilja M. Nolte, Albertine J. Oldehinkel, Matthias Olden, Ken K. Ong, Sandosh Padmanabhan, Lavinia Paternoster, Jeremiah Perez, Markus Perola, Annette Peters, Ulrike Peters, Patricia A. Peyser, Inga Prokopenko, Hannu Puolijoki, Olli T. Raitakari, Tuomo Rankinen, Laura J. Rasmussen‐Torvik, Rajesh Rawal, Paul M. Ridker, Lynda M. Rose, Igor Rudan, Cinzia Sarti, Mark A. Sarzynski, Kai Savonen, William R. Scott, Serena Sanna, Alan R. Shuldiner, Günther Silbernagel, Blair H. Smith, Jennifer A. Smith, Harold Snieder, Alena Stančáková, Barbara Sternfeld, Amy J. Swift, Tuija Tammelin, Barbara Thorand, Dorothée Thuillier, Liesbeth Vandenput, Henrik Vestergaard, Jana V. van Vliet‐Ostaptchouk, Marie‐Claude Vohl, Uwe Völker, Gérard Waeber, Mark Walker, Sarah H. Wild, Andrew Wong, Alan F. Wright, M. Carola Zillikens, Niha Zubair, Christopher A. Haiman, Loı̈c Le Marchand, Ulf Gyllensten, Claes Ohlsson, Albert Hofman, Fernando Rivadeneira, André G. Uitterlinden, Louis Përusse, James F. Wilson, Caroline Hayward, Ozren Polašek, Francesco Cucca, Kristian Hveem, Catharina A. Hartman, Anke Tönjes, Stefania Bandinelli, Lyle J. Palmer, Sharon L. R. Kardia, Rainer Rauramaa, Thorkild I. A. Sørensen, Jaakko Tuomilehto, Veikko Salomaa, Brenda W.J.H. Penninx, Eco J. C. de Geus, Dorret I. Boomsma, Terho Lehtimäki, Massimo Mangino, Markku Laakso, Claude Bouchard, Nicholas G. Martin, Diana Kuh, Ching‐Ti Liu, Allan Linneberg, Winfried März, Konstantin Strauch, Mika Kivimäki, Tamara B. Harris, Vilmundur Guðnason, Henry Völzke, Lu Qi, Marjo‐Riitta Järvelin, John C. Chambers, Jaspal S. Kooner, Philippe Froguel, Charles Kooperberg, Péter Vollenweider, Göran Hallmans, Torben Hansen, Oluf Pedersen, Andres Metspalu, Nicholas J. Wareham, Claudia Langenberg, David R. Weir, David J. Porteous, Eric Boerwinkle, Daniel I. Chasman, Gonçalo R. Abecasis, Inês Barroso, Mark I. McCarthy, Timothy M. Frayling, Jeffrey R. O’Connell, Cornelia M. van Duijn, Michael Boehnke, Iris M. Heid, Karen L. Mohlke, David P. Strachan, Caroline S. Fox, Joel N. Hirschhorn, Robert J. Klein, Andrew D. Johnson, Ingrid B. Borecki, Paul W. Franks, Kari E. North, L. Adrienne Cupples, Ruth J. F. Loos, Tuomas O. Kilpeläinen
Bibliographic record
VenuePLoS Genetics · 2017
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsInstitute of Population and Public HealthUniversité LavalCentre for Global Health Research
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Center for Research ResourcesNational Institute of Environmental Health SciencesNational Cancer InstituteNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Eye InstituteNational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthChinese Society of Clinical OncologyNovo Nordisk FondenTartu ÜlikoolVetenskapsrådetNational Institute on Drug AbusePaavo Nurmen SäätiöNovo NordiskHjärt-LungfondenLundbeckfondenNational Institute on Minority Health and Health DisparitiesTampereen TuberkuloosisäätiöKelaUmeå UniversitetSteno Diabetes Center CopenhagenSvenska Sällskapet för Medicinsk ForskningNational Human Genome Research InstituteRussian Foundation for Basic ResearchU.S. Department of Veterans AffairsSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungNational Science FoundationNIHR BioResourceTexas Health and Human Services CommissionRoyal SocietyNational Center for Advancing Translational SciencesMedical Research CouncilLes Laboratories Pierre FabreBritish Heart FoundationNederlandse Organisatie voor Wetenschappelijk OnderzoekWellcome TrustUniversitair Medisch Centrum GroningenNational Institute of Diabetes and Digestive and Kidney DiseasesSanofiNational Institute on AgingNational Institute for Health and Care ResearchStiftelsen för Strategisk Forskning
KeywordsWaistBiologyObesityGenome-wide association studyCircumferenceGeneticsMeta-analysisLocus (genetics)GenomeFTO geneQuantitative trait locusPhysical activityReplicateGeneBioinformaticsInternal medicinePolymorphism (computer science)EndocrinologySingle-nucleotide polymorphismMedicinePhysical therapyAlleleGenotype
Abstract
OpenAlex records an abstract for this work, but it could not be fetched just now.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.017
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.007 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.188
GPT teacher head0.405
Teacher spread0.216 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations343
Published2017
Admission routes1
Has abstractyes