0726 MOOD AND SLEEP QUALITY SYMPTOMS ARE NOT LINKED TO MILD COGNITIVE IMPAIRMENT IN RAPID EYE MOVEMENT SLEEP BEHAVIOR DISORDER
Bibliographic record
Abstract
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by abnormal motor activity during REM sleep. RBD patients are at high risk to develop mild cognitive impairment (MCI) and synucleinopathies, such as Parkinson’s disease and dementia with Lewy bodies. We aimed to compare self-reported mood (anxiety, depression) and sleep quality (insomnia and excessive daytime sleepiness) complaints between RBD patients with MCI (RBD-MCI), RBD patients without MCI (RBD-nMCI) and healthy subjects. One hundred and fifty-eight participants, including 43 RBD-MCI patients, 52 RBD-nMCI patients, and 97 healthy subjects underwent a polysomnography, a neuropsychological assessment for MCI diagnosis, and a neurological exam. Self-reported questionnaires for mood [Beck Anxiety Inventory (BAI), Beck Depression Inventory II (BDI-II)] and sleep quality [Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS)] were also administered. One-way analysis of variance with Bonferroni post-hoc tests were performed to assess differences between the three groups. No significant between-group difference was found for age, gender, RBD duration, or ESS scores. Between-group differences were found for the BAI (F(2,171) = 10.34, p<0.05), BDI-II (F(2,187) = 9.15, p<0.05), and ISI (F(2,158) = 12.50, p<0.05). Post-hoc analysis revealed that both RBD groups (with or without MCI) reported more anxiety, depressive, and insomnia symptoms compared to healthy subjects (p<0.05). However, within RBD, no significant difference on mood and sleep questionnaires was found between those with or without MCI. Self-reported mood and sleep (insomnia) complaints are frequent in RBD patients, but no association were found with their cognitive status. Further studies are needed to better validate the questionnaires used in the present study in a RBD population, and to determine the predictive value of mood and sleep complaints for the development of synucleinopathies. Canadian Institutes of Health Research and W. Garfield Weston Foundation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".