High affinity IL-2 receptor (CD25) expression among Chronic Lymphocytic leukemia (CLL) patients is independent of mutational status and ZAP-70 positivitys
Bibliographic record
Abstract
Background: Recent studies have suggested promising roles for immunotherapy through CD40 ligand /IL-2 signaling pathway in CLL patients. Differential expression of the IL-2 receptor (IL-2 R) has been reported in CLL and other B-cell malignancies. Because CLL is divided into two distinct prognostic groups (based on the level of somatic hypermutation or alternatively on the presence or absence of ZAP-70), it is important to determine the correlation of IL-2 R expression with mutational status and/or ZAP-70 positivity in CLL for better patient group stratification in clinical trials. 
 Methods: In this study, 132 pts (82 M/50F; M: F 1.6) with an age range of 33-91 yrs (median 66 yrs) were included. Of these, 67/132 (51%) were found to be CD25+, 44/132 (33%) CD25- and 16% were CD25 dim (not further analyzed). In terms of ZAP positivity, 19/132 (14%) pts were ZAP-70+ and 113 (86%) were ZAP-70-. 
 Results: Mutational data (n=93) revealed 60/93 (65%) patients with SHM and 33/ 93 (35%) without. Correlation between ZAP-70+ and absence of SHM was highly significant (p< 0.0001), however, no statistically significant correlation was noted between CD25 expression and SHM (p= 0.331) or ZAP positivity (p= 0.785). 
 Conclusions: This data suggests that IL-2 R expression, although noted among a significant proportion of patients with B-CLL, is independent of somatic hypermutation or ZAP-70 expression. This observation will be important in evaluation of clinical efficacy of immunotherapy among CLL patients, and points to the existence of another mechanism for the presence of IL-2 R in these patients. 
 
 Abbreviations: B-CLL (B-cell Chronic Lymphocytic Leukemia), SHM (Somatic Hypermutation)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.006 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.011 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".