GSK-3 Beta Inhibition More Strongly Blocks Acquisition Than Expression of Amphetamine-produced Conditioned Place Preference in Rats
Bibliographic record
Abstract
Dopamine (DA) has been implicated in behavioural sensitization and incentive learning. The signaling molecule glycogen synthase kinase-3β (GSK-3β), activated downstream of DA D2-like receptors, affects DA-mediated behaviours. For example, inhibition of GSK-3β attenuates locomotor sensitization to psychomotor stimulant drugs. Few studies have examined the effects of GSK-3β inhibition in incentive learning paradigms. We examined the effects of GSK-3β inhibition on incentive learning produced by amphetamine (1.5 mg/kg) in the conditioned place preference (CPP) paradigm. The selective GSK-3 inhibitor SB 216763 was administered intraperitoneally to male Wistar rats at doses of 1.0, 2.0, and 2.5 mg/kg during the acquisition or expression phase. Due to studies more strongly implicating signaling molecules in acquisition rather than expression of learning, we hypothesized a block of acquisition of CPP at doses that fail to block expression of CPP. Results supported this hypothesis: the 1.0 mg/kg dose of SB 216763 failed to block either acquisition or expression of CPP; the 2.0 mg/kg dose blocked acquisition, but not expression of CPP; and the 2.5 mg/kg dose blocked both acquisition and expression of CPP. These results indicate that inhibiting GSK-3β may attenuate incentive learning differentially in acquisition versus expression of conditioning. (Funded by NSERC)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".