Abstract 416: Chloride Ion Contributes to the Hypertension Induced by Central NaCl
Bibliographic record
Abstract
Previous studies in salt-sensitive animal strains suggest that an increase in the level of sodium in the cerebrospinal fluid (CSF [Na]) is crucial for the development of hypertension induced by a high salt diet. Although chronic intracerebroventricular (icv) infusions of NaCl-rich artificial CSF (NaCl-rich aCSF) are frequently used to study the mechanisms of the hypertension caused by high salt diet and/or elevated CSF [Na], the contribution of chronic increased CSF [Cl] to the hypertensive response has not been examined. In the present study, we compared the effects on blood pressure of chronic (10 day) icv infusions of NaCl-rich aCSF vs. similar infusions in which excess Na+ or Cl- was substituted with another ion in wild-type (WT) mice and in knockout/knockin mice with a ouabain-resistant endogenous Na, K-ATPase α2 subunit (α2 R/R ). The latter mice are known to lack a pressor response to icv NaCl-rich aCSF. Mean arterial pressure (MAP) and heart rate (HR) on day 10 of infusion were (mean ± S.E.M., n = 4-5 per group: These studies suggest that both elevated CSF [Na] and CSF [Cl] contribute to the pressor response to increased CSF [NaCl] via a common mechanism: binding of endogenous ouabain to the Na, K-ATPase α2 isoform.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".