Abstract 416: Chloride Ion Contributes to the Hypertension Induced by Central NaCl
Bibliographic record
Abstract
Previous studies in salt-sensitive animal strains suggest that an increase in the level of sodium in the cerebrospinal fluid (CSF [Na]) is crucial for the development of hypertension induced by a high salt diet. Although chronic intracerebroventricular (icv) infusions of NaCl-rich artificial CSF (NaCl-rich aCSF) are frequently used to study the mechanisms of the hypertension caused by high salt diet and/or elevated CSF [Na], the contribution of chronic increased CSF [Cl] to the hypertensive response has not been examined. In the present study, we compared the effects on blood pressure of chronic (10 day) icv infusions of NaCl-rich aCSF vs. similar infusions in which excess Na+ or Cl- was substituted with another ion in wild-type (WT) mice and in knockout/knockin mice with a ouabain-resistant endogenous Na, K-ATPase α2 subunit (α2 R/R ). The latter mice are known to lack a pressor response to icv NaCl-rich aCSF. Mean arterial pressure (MAP) and heart rate (HR) on day 10 of infusion were (mean ± S.E.M., n = 4-5 per group: These studies suggest that both elevated CSF [Na] and CSF [Cl] contribute to the pressor response to increased CSF [NaCl] via a common mechanism: binding of endogenous ouabain to the Na, K-ATPase α2 isoform.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".