MP756EVALUATION OF THE ONE YEAR FOLLOW UP OF DIALYSIS PTS BY RAPID NEUROPSYCHOLOGICAL SCREENING BATTERY
Bibliographic record
Abstract
INTRODUCTION AND AIMS: In the international literature there is growing evidence about alteration in cognitive function in patients with renal replacement therapy (RRT). It seems that the executive domain is mainly involved. Further, we know little about possible differences in patients undergoing different treatments. The aim of the present study is to evaluate the executive domain of dialysis pts after 1 year of follow up by rapid neuropsychological screening battery. METHODS: We enrolled pts in chronic dialysis (HD or PD) from at least 3 months. Executive functioning was assessed in two time points (t0 and after 1 year) by Montreal Cognitive Assessment (MoCA) that, according to Italian normative data, can be divided into subtest (Santangelo et al., 2015). We divided the population based on Equivalent Score (ES): pathological (0,1 ES) and not pathological (2,3,4 ES). Statistical analysis was performed with SPSS21 software. RESULTS: We screened 207 dialysis pts: 133 were enrolled at T0 and 104 were enrolled in T1 period. 29 pts dropped out for different reasons (e.g. death, refusal). In the present study we compared only the pts that completed the test both at T0 and T1. At T0 the sample was composed of 47 (45.2%) HD pts and 57 (54.8%) PD pts. After a median follow up of 12 (8- 16) month the mean MoCA total score was significantly decreased (T0, 23.47 ± 4.01 vs T1, 22.89 ± 4.15; p= 0.027). Demographic data and MoCA subtest are shown in Table 1. Comparing each domain, we found a significantly difference of the percentage of patients (19.2%) that changed from not pathological (2,3,4 ES) to pathological (0, 1 ES) in executive domain from T0 to T1. In fact, at T1 the 41.3% of the sample shows difficulties in this domain. Moreover we compared the metabolic parameters between T0 and T1 (hemoglobin, creatinine, urea, sodium, potassium, calcium, chlorine, phosphorus, vitamin D, FGF23, protein C reactive, intact PTH, cholesterol and triglycerides) in patients (20 pts) that changed from not pathological to pathological in executive domain. We did not find any statistically differences. MP756 Figure
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".