Comparison of the inhibition of recombinant and native heme oxygenase-1 (HO-1) activity by the imidazoledioxolane compound QC-15
Bibliographic record
Abstract
Recombinant full-length and truncated forms of human heme oxygenase-1 (hHO-1) were compared with their native, microsomal HO-1 counterpart from rat spleen tissue, with respect to their inhibition by the imidazole-dioxolane HO inhibitor QC-15. Rat native HO-1 was maximally inhibited to the greatest extent (7.53 ± 1.51% of control activity), as compared to recombinant, full-length hHO-1 (55.55 ± 6.08%), and also truncated hHO-1 (72.17 ± 5.94%). The greater susceptibility of native HO-1 to QC-15 inhibition may be attributed to the presence of its C-terminal transmembrane domain (CTD) and its anchoring into the endoplasmic reticulum (ER). If so, membrane-anchored, recombinant, full-length hHO-1 may replace the current HO-1 microsomal model derived from rat spleen, in future in vitro inhibition studies. A better understanding of HO-1 inhibitors like QC-15 may lead to chemotherapeutics that prevent tumour cells from taking advantage of the cytoprotective nature of the HO system.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".