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Record W2620753850 · doi:10.1016/j.jmb.2017.05.025

Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10

2017· article· en· W2620753850 on OpenAlexafffund
Wei Zhang, Maria A. Sartori, Taras Makhnevych, Kelly Federowicz, Xiaohui Dong, Li Liu, Satra Nim, Aiping Dong, Jingsong Yang, Yanjun Li, Dania Haddad, Andreas Ernst, Dirk A. Heerding, Yufeng Tong, Jason Moffat, Sachdev S. Sidhu

Bibliographic record

VenueJournal of Molecular Biology · 2017
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicUbiquitin and proteasome pathways
Canadian institutionsStructural Genomics ConsortiumUniversity of Toronto
FundersEshelman Institute for Innovation, University of North Carolina at Chapel HillJanssen BiotechCanadian Institutes of Health ResearchInnovative Medicines InitiativeMinistero dello Sviluppo EconomicoMitacsU.S. Department of EnergyNational Natural Science Foundation of ChinaMerckOntario Ministry of Economic Development and InnovationCanadian Council for Indigenous BusinessAbbVieNovartis PharmaCanada Foundation for InnovationArgonne National LaboratoryOntario Genomics InstituteCanadian Cancer Society Research InstituteOntario GenomicsFundação de Amparo à Pesquisa do Estado de São PauloGenome CanadaEuropean Federation of Pharmaceutical Industries and AssociationsTakeda Pharmaceuticals U.S.A.PfizerBoehringer IngelheimWellcome Trust
KeywordsUbiquitinUbiquitin ligaseDeubiquitinating enzymeMdm2BiologyProteasomeCell biologyDrug discoveryCancer researchApoptosisBiochemistryGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.029
Threshold uncertainty score0.356

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.291
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations54
Published2017
Admission routes2
Has abstractno

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