Group 2 innate lymphoid cells collaborate with dendritic cells to potentiate memory Th2 cell responses.
Bibliographic record
Abstract
Abstract Rapid memory CD4+ T helper 2 (Th2) cell activation during allergic inflammation requires their recruitment into the affected tissue. Tissue-resident innate immune cells such as dendritic cells (DC) are essential for orchestrating local memory Th2 cell responses. We now know that tissue-resident group 2 innate lymphoid cells (ILC2) are an important innate source of type-2 cytokines in barrier sites. However, it is currently not known if ILC2 remain functionally important after the generation of adaptive Th2 cells. Here we demonstrate that group 2 innate lymphoid cells (ILC2) play a critical role in memory Th2 cell responses. By targeted ILC2 depletion, using ILC2-specific diphtheria toxin receptor expressing iCOS-T mice, we show a profound impairment in Th2 cell localization to the lungs and skin of sensitized mice after allergen re-challenge. Mechanistically, ILC2-derived IL-13 is critical for eliciting IRF4+CD11b+CD103− DCs to produce the Th2 cell-attracting chemokine CCL17. Consequently, the sentinel function of DCs is contingent on ILC2s for the generation of an efficient memory Th2 cell response. These results elucidate a key new innate mechanism in the regulation of the adaptive memory immune response to allergens.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".