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Record W2624031057 · doi:10.1016/s2213-8587(17)30194-8

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

2017· article· en· W2624031057 on OpenAlexaff
John R. Petrie, Nish Chaturvedi, Ian Ford, Martijn C.G.J. Brouwers, Nicola Greenlaw, Therese Tillin, Irene Hramiak, Alun D. Hughes, Alicia J. Jenkins, Barbara E.K. Klein, Ronald Klein, Teik Chye Ooi, Peter Rossing, Coen D.A. Stehouwer, Naveed Sattar, Helen M. Colhoun, Helen Nickerson, Olivia Lou, Srijana Dutta, J Haw, Caroline Anderson, Sharon Kean, Emma C. Thomson, Louis J. Gillespie, James I. Gibb, Anthony Keech, Katherine March, Scott C. Williams, Emma Coady, Michael Bots, Jean‐Luc Dreyer, T Jan, Koby Sheffy, Ravit Lusky, Shlomit Peleg, Angela C. Shore, David Carty, Peter T. Donnan, Miles D. Witham, Andrew Adler, Eva Lonn, Petra Rauchhaus, Robert S. Lindsay, Jurgen Van-Melckebeke, Terence G. Hamill, Leah Cuthbertson, Andrew J. Murray, Lisa Jolly, Elizabeth R. Miller, Josie N. Hair, Alan Bell, S Carmichael, Elizabeth Douglas, Pamela Surtees, Eleanor Dinnett, J. Joshua Allan, Chalmers Watson, M McLaughlin, G Brindley, E Smillie, D.W. Motherwell, S MacDonald, Peter Ellis, Dennis O. Stuart, Mary E. Travers, Sarah Brearley, Lynn Greig, Peter G. Colman, Alison Nankervis, S Forulanos, Daniel J. West, Stuart L. Vaughan, M Bjorasen, John Donlan, J Vrazas, David N. O’Neal, Jodie C. Horsburgh, H Pater, Sarah Kent, Stephen M. Twigg, Gregory Fulcher, R Denner, Agata K. Piotrowicz, Andrzej S. Januszewski, Andres Coy, Terri Paul, Christine F. McDonald, S Tereschyn, Norine Schmidt, M Weingert, H Heard, Susan J. Burke, TC Ooi, Heather Lochnan, Alexander Sorisky, Janine Malcolm, Julie Maranger, Colette Favreau, S Petherick, Katrina Boles, Tine W. Hansen, Sten Lund, Bianca Hemmingsen, Natasha Thorogood, K Green, Thompson Robinson, K Abouglilia, D Nayman, Clare Miller, Roderick E. Warren, Kunihiko Aizawa, M. Balasubramani, Štefan Tóth, K Harvey, G. G. Birch, Stephen L. Atkin, Thozhukat Sathyapalan, Archana James, Zeeshan Javed, John Wilding, Barbara K. Martin, Stephen Birch, Annabelle Wilcox, Neil Watson, Nick Oliver, Narvada Jugnee, Martin K. Rutter, Tolga Turgut, Amiya Shaju, S Yau, S Subin, MB Walker, Dianne Wake, Ann Millward, Pei Nee Chong, Marienne Hibbert, Jacob George, Nicolaas C. Schaper, J Pinxt, Jos Op ’t Roodt, Sam Phillips, Lynne Murray, Linda Sleigh, A. Collier, LE Sit, Karen Allan, Jennifer Cook, Kaitryn Campbell, L Hodge, Graham Leese, G Reekie, Alan Jaap, Amanda Sudworth, Alexander White, John McKnight, L Steven, Gerard McKay, Andrea Llano, Gemma Currie, E Lennon, Jeanette M. Johnstone, Kelly M. Shields

Bibliographic record

VenueThe Lancet Diabetes & Endocrinology · 2017
Typearticle
Languageen
FieldMedicine
TopicDiabetes Management and Research
Canadian institutionsOttawa HospitalSt Joseph's Health Care
FundersBritish Heart FoundationSteno Diabetes Center Copenhagen
KeywordsMedicineMetforminType 2 diabetesPlaceboDiabetes mellitusInternal medicineRandomized controlled trialMEDLINEEndocrinologyAlternative medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.029

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0050.004
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0020.002
Open science0.0010.001
Research integrity0.0040.003
Insufficient payload (model declined to judge)0.0090.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.282
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations347
Published2017
Admission routes1
Has abstractno

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