Practical Synthesis of Two Different Pseudoenantiomeric Organocatalysts with <i>cis</i>‐Cyclohexanediamine Structure from a Common Chiral Source
Bibliographic record
Abstract
Abstract An approach has been developed for the practical synthesis of two different, structurally robust, pseudoenantiomeric amino Tf‐amido organocatalysts with a cis ‐1,2‐cyclohexanediamine structure. These pseudoenantiomeric organocatalysts, which are very useful for the practical synthesis of both enantiomeric aldol products, are easily prepared from commercially available cis ‐4‐cyclohexene‐1,2‐dicarboxylic acid in a four‐step sequence. The Diels–Alder strategy of 2‐alkyl‐1,3‐butadiene and maleic anhydride would provide a general approach to the facile synthesis of various pseudoenantiomeric organocatalysts.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".