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Record W2632247119 · doi:10.1002/jbm.a.30859

Cyclic biaxial strain affects U937 macrophage‐like morphology and enzymatic activities

2006· article· en· W2632247119 on OpenAlexaff
Loren A. Matheson, Geoffrey N. Maksym, J. Paul Santerre, Rosalind S. Labow

Bibliographic record

VenueJournal of Biomedical Materials Research Part A · 2006
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCellular Mechanics and Interactions
Canadian institutionsUniversity of TorontoDalhousie UniversityUniversity of Ottawa
Fundersnot available
KeywordsVinculinStrain (injury)CytoskeletonActinMaterials scienceConfusionFocal adhesionCell adhesionU937 cellBiophysicsMolecular biologyAdhesionCellCell cultureBiologyCell biologyBiochemistryGeneticsComposite materialAnatomy

Abstract

fetched live from OpenAlex

The authors have brought to our attention that there was an error in the article listed above published in J Biomed Mater Res 2006; 76A(1): 52–62. In Figure 4C the molecular weight of vinculin was inadvertently referred to as 50kDa when it should have been 117kDa. See revised figure on the next page. We regret any confusion caused by this error. The organization of U937 cell cytoskeletal and focal adhesion proteins is altered in response to strain. (A) Representative fluorescence micrographs of U937 cells labeled for F-actin (i, ii, and iii), vinculin (iv, v, and vi) or chromatin (vii, viii, and ix); static cells (i, iv and vii), cells strained at the center of the well where the strain is predominantly equi-biaxial (ii, v, and vi), or cells strained at the edge of the well where the strain is predominantly uniaxial (iii, vi, and ix). Arrows indicate the direction of the strain. (B) The graph shows the relative fluorescence intensity of both vinculin and actin protein per well in static (black bars) and strained (white bars) cells. (C) Immunoblots demonstrate the protein levels of actin and vinculin as loaded by a standard amount of DNA. [Color figure can be viewed in the online issue, which is available at http://www.interscience.wiley.com.]

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.326
Teacher spread0.304 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2006
Admission routes1
Has abstractyes

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Same venueJournal of Biomedical Materials Research Part ASame topicCellular Mechanics and InteractionsFrench-language works237,207