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Record W2636610941 · doi:10.1093/cid/cix406

Favipiravir and Ribavirin Treatment of Epidemiologically Linked Cases of Lassa Fever

2017· article· en· W2636610941 on OpenAlexfundno aff
Vanessa Raabe, Gerrit Kann, Bruce S. Ribner, Andrés Morales, Jay B. Varkey, Aneesh K. Mehta, G. Marshall Lyon, Sharon Vanairsdale, Kelly Faber, Stephan Becker, Markus Eickmann, Thomas Strecker, Shelley Brown, Ketan Patel, Philipp de Leuw, Gundolf Schuettfort, Christoph Stephan, Holger F. Rabenau, John D. Klena, Pierre E. Rollin, Anita K. McElroy, Ute Ströher, Stuart T. Nichol, Colleen S. Kraft, Timo Wolf, Sonia Bell, Catherine Maloney, Pam Cosper, Nancye Feistritzer, John Lewin, Bryce Gartland, Ira Horowitz, David Pugh, Chad W.M. Ritenour, Jerry P. Lewis, D. M. Hatcher, Linda Scott-Harris, Lynne Ometer, K J Hardy, Robert Jackson, Samantha Thomas, Toni Ash, Christopher O. Barnes, Jamie Breedlove, Bob Bridgman, Lane Darragh, Tracey Daye, Dustin Hillis, Crystal H Johnson, J.E. Johnson, Danni LaFond, Courtney Lyons, Josia Mamora, Anna McCord, Samantha McDaniel, Haley Morgan, Jill S. Morgan, Alexander Sanchez, Marissa Simon, Jason Slabach, Kevin Tirado, Sally Watkins, Terrica Wilson, Ken Logan, Eileen M. Burd, John F. Cardella, Brenda L. Eaves, Crystal Evans, Charles E. Hill, Doris Igwe, Karen Jenkins, Maureen Lindsey, Jordan Magee, Stacy McCarthy, Randall K. Powers, James Ritchie, Jan Pack, Susan Rogers, Patricia Olinger, R. Kalpana, Scott W. Thomaston, Esmeralda Meyer, Emily Beck, Paula DesRoches, Cynthia R Hall, Celeste Walker, Esther Baker, Betsy Hackman, Robin Brown-Haithco, Faith Richardson, Art Krasilovsky, C. Jordan, Sue Matthews, Marilyn Hazzard Lineberger, Paula G Gomes, Gentrice McGee, Porcia Jones, James Cain, Roderick W. Davis, Tyrone Johnson, Tyrone Pickett, Anthony Shaw, Tenina Truesdale, A. N. Isakov, Sam Shartar, Wade Miles, Aaron Jamison, John Arévalo, Gail Stallings, Janet Christenbury, Vince Dollard, Melanie De Gennaro, Holly Korschun, Tom Ziegler, Daniel Griffith, Nisha Davé

Bibliographic record

VenueClinical Infectious Diseases · 2017
Typearticle
Languageen
FieldMedicine
TopicViral Infections and Outbreaks Research
Canadian institutionsnot available
FundersNational Institutes of HealthValeant Pharmaceuticals International
KeywordsLassa feverFavipiravirRibavirinMedicineVirologyLassa virusSexual transmissionTransmission (telecommunications)VirusInternal medicineDiseaseCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)Hepatitis C virus

Abstract

fetched live from OpenAlex

Two patients with Lassa fever are described who are the first human cases treated with a combination of ribavirin and favipiravir. Both patients survived but developed transaminitis and had prolonged detectable virus RNA in blood and semen, suggesting that the possibility of sexual transmission of Lassa virus should be considered.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.184
GPT teacher head0.487
Teacher spread0.303 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations141
Published2017
Admission routes1
Has abstractyes

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