Travel-Associated Zika Virus Disease
Bibliographic record
Abstract
Letters20 June 2017Travel-Associated Zika Virus DiseaseDavidson H. Hamer, MD, Lin H. Chen, MD, Michael Libman, MD, Martin P. Grobusch, MD, PhD, and Douglas H. Esposito, MD, MPHDavidson H. Hamer, MDFrom Boston University School of Public Health, Boston, Massachusetts; Mount Auburn Hospital, Cambridge, Massachusetts; McGill University, Montreal, Quebec, Canada; University of Amsterdam, Amsterdam, the Netherlands; Centers for Disease Control and Prevention, Atlanta, Georgia.Search for more papers by this author, Lin H. Chen, MDFrom Boston University School of Public Health, Boston, Massachusetts; Mount Auburn Hospital, Cambridge, Massachusetts; McGill University, Montreal, Quebec, Canada; University of Amsterdam, Amsterdam, the Netherlands; Centers for Disease Control and Prevention, Atlanta, Georgia.Search for more papers by this author, Michael Libman, MDFrom Boston University School of Public Health, Boston, Massachusetts; Mount Auburn Hospital, Cambridge, Massachusetts; McGill University, Montreal, Quebec, Canada; University of Amsterdam, Amsterdam, the Netherlands; Centers for Disease Control and Prevention, Atlanta, Georgia.Search for more papers by this author, Martin P. Grobusch, MD, PhDFrom Boston University School of Public Health, Boston, Massachusetts; Mount Auburn Hospital, Cambridge, Massachusetts; McGill University, Montreal, Quebec, Canada; University of Amsterdam, Amsterdam, the Netherlands; Centers for Disease Control and Prevention, Atlanta, Georgia.Search for more papers by this author, and Douglas H. Esposito, MD, MPHFrom Boston University School of Public Health, Boston, Massachusetts; Mount Auburn Hospital, Cambridge, Massachusetts; McGill University, Montreal, Quebec, Canada; University of Amsterdam, Amsterdam, the Netherlands; Centers for Disease Control and Prevention, Atlanta, Georgia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0195 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Liuzzi and colleagues' positive feedback on our article, which summarized Zika virus infections reported to GeoSentinel during the first months of the outbreak in the Americas. They describe the results from their screening algorithm for testing women who are planning to conceive or are already pregnant and their sexual partners after travel to an area with risk for this virus even when those partners are asymptomatic. Sexual transmission of Zika virus has been well-established, including transmission from asymptomatic men to their female partners (1). Furthermore, Zika virus RNA has been detected in semen for up ...References1. Hamer DH, Wilson ME, Jean J, Chen LH. Epidemiology, prevention, and potential future treatments of sexually transmitted Zika virus infection. Curr Infect Dis Rep. 2017;19:16. [PMID: 28281082] doi:10.1007/s11908-017-0571-z CrossrefMedlineGoogle Scholar2. Nicastri E, Castilletti C, Liuzzi G, Iannetta M, Capobianchi MR, Ippolito G. Persistent detection of Zika virus RNA in semen for six months after symptom onset in a traveller returning from Haiti to Italy, February 2016. Euro Surveill. 2016;21. [PMID: 27541989] doi:10.2807/1560-7917.ES.2016.21.32.30314 CrossrefMedlineGoogle Scholar3. Centers for Disease Control and Prevention. Clinical guidance for pregnant travelers who live in an area without risk of Zika. 2017. Accessed at www.cdc.gov/zika/hc-providers/pregnant-women/asymptomatic-pregnant-travel.html on 28 March 2017. Google Scholar4. Felix AC, Souza NC, Figueiredo WM, Costa AA, Inenami M, da Silva RM, et al. Cross reactivity of commercial anti-dengue immunoassays in patients with acute Zika virus infection. J Med Virol. 2017. [PMID: 28229481] doi:10.1002/jmv.24789 CrossrefMedlineGoogle Scholar5. Charrel RN, Leparc-Goffart I, Pas S, de Lamballerie X, Koopmans M, Reusken C. Background review for diagnostic test development for Zika virus infection. Bull World Health Organ. 2016;94:574-84D. [PMID: 27516635] doi:10.2471/BLT.16.171207 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Boston University School of Public Health, Boston, Massachusetts; Mount Auburn Hospital, Cambridge, Massachusetts; McGill University, Montreal, Quebec, Canada; University of Amsterdam, Amsterdam, the Netherlands; Centers for Disease Control and Prevention, Atlanta, Georgia.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-1842. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTravel-Associated Zika Virus Disease Acquired in the Americas Through February 2016 Davidson H. Hamer , Kira A. Barbre , Lin H. Chen , Martin P. Grobusch , Patricia Schlagenhauf , Abraham Goorhuis , Perry J.J. van Genderen , Israel Molina , Hilmir Asgeirsson , Phyllis E. Kozarsky , Eric Caumes , Stefan H. Hagmann , Frank P. Mockenhaupt , Gilles Eperon , Elizabeth D. Barnett , Emmanuel Bottieau , Andrea K. Boggild , Philippe Gautret , Noreen A. Hynes , Susan Kuhn , R. Ryan Lash , Karin Leder , Michael Libman , Denis J.M. Malvy , Cecilia Perret , Camilla Rothe , Eli Schwartz , Annelies Wilder-Smith , Martin S. Cetron , Douglas H. Esposito , and Travel-Associated Zika Virus Disease Giuseppina Liuzzi , Concetta Castilletti , Francesco Vairo , Emanuele Nicastri , and Giuseppe Ippolito Metrics Cited byImported Arbovirus Infections in Spain, 2009–2018 20 June 2017Volume 166, Issue 12Page: 913-914KeywordsDisclosureHematologic testsNegative predictive valuePregnancyRNAResearch laboratoriesRisk assessmentsSemenSpecificityZika virus ePublished: 20 June 2017 Issue Published: 20 June 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.011 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.088 | 0.024 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".