The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial.
Bibliographic record
Abstract
5738 CC10 is a 10-kDa protein secreted by nonciliated Clara cells which are progenitor cells in the bronchiolar epithelium. CC10 is infrequently expressed in non-small cell lung cancer (NSCLC) and overexpression of CC10 in NSCLC cell lines results in a less malignant phenotype. CC10 levels in bronchoalveolar lavage fluid (BAL) and serum are significantly lower in current smokers compared with healthy non-smokers, but it is not known whether long term smoking cessation results in restoration of CC10 expression. To determine whether smoking cessation plays a role in up-regulating the BAL and plasma CC10 levels, we used specimens collected during a chemoprevention trial assessing the efficacy of budesonide vs. placebo to regress bronchial dysplasia in current (n=80) and former (n=22) smokers. CC10 was measured by a competitive ELISA in baseline BAL and plasma specimens. Interestingly, current smokers appeared to have significantly lower baseline plasma CC10 levels compared to former smokers [mean 36.7 (95% CI: 29.4∼44.1); range (5.0∼171.0) ng/ml for current smokers, and mean 58.1 (95%CI: 39.9∼76.2); range (23.0∼175.0) ng/ml for former smokers, p
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".