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Record W2687519416 · doi:10.1038/nn.4592

Germline Chd8 haploinsufficiency alters brain development in mouse

2017· article· en· W2687519416 on OpenAlexafffund
Andrea Gompers, Linda Su-Feher, Jacob Ellegood, Nycole A. Copping, M. Asrafuzzaman Riyadh, Tyler W. Stradleigh, Michael C. Pride, Melanie D. Schaffler, A. Ayanna Wade, Rinaldo Catta-Preta, Iva Zdilar, Shreya Louis, Gaurav Kaushik, Brandon J. Mannion, Ingrid Plajzer-Frick, Veena Afzal, Axel Visel, L Pennacchio, Diane E. Dickel, Jason P. Lerch, Jacqueline N. Crawley, Konstantinos Zarbalis, Jill L. Silverman, Alex S. Nord

Bibliographic record

VenueNature Neuroscience · 2017
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomics and Chromatin Dynamics
Canadian institutionsUniversity of TorontoHospital for Sick Children
FundersNational Institute of Dental and Craniofacial ResearchNational Human Genome Research InstituteNational Institutes of HealthNational Institute of Neurological Disorders and StrokeNational Institute of General Medical SciencesMIND Institute, University of California, DavisUniversity of California BerkeleyFondation Brain CanadaLawrence Berkeley National LaboratoryNational Heart, Lung, and Blood InstituteOntario Brain InstituteConselho Nacional de Desenvolvimento Científico e TecnológicoCiência sem FronteirasIntellectual and Developmental Disabilities Research CenterUniversity of California, DavisEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentU.S. Department of Energy
KeywordsHaploinsufficiencyNeuroscienceBiologyAutismChromatin remodelingNeural developmentChromatinGeneticsPhenotypeGenePsychology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.000
Science and technology studies0.0000.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.261
Teacher spread0.254 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations280
Published2017
Admission routes2
Has abstractno

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