MétaCan
Menu
Back to cohort
Record W2724938313 · doi:10.1038/nature22969

Fine-mapping inflammatory bowel disease loci to single-variant resolution

2017· article· en· W2724938313 on OpenAlexafffund
Hailiang Huang, Ming Fang, Luke Jostins, Maša Umićević Mirkov, Gabrielle Boucher, Carl A. Anderson, Vibeke Andersen, Isabelle Cleynen, Adrián Cortés, François Crins, Mauro D’Amato, Valérie Deffontaine, Julia Dmitrieva, Elisa Docampo, Mahmoud Elansary, Kyle Kai‐How Farh, André Franke, Ann-Stephan Gori, Philippe Goyette, Jonas Halfvarson, Talin Haritunians, Jo Knight, Ian C. Lawrance, Charlie W. Lees, Édouard Louis, Rob Mariman, T.H.E. Meuwissen, Myriam Mni, Yukihide Momozawa, Miles Parkes, Sarah L. Spain, Emilie Théâtre, Gosia Trynka, Jack Satsangi, Suzanne van Sommeren, Séverine Vermeire, Ramnik J. Xavier, Rinse K. Weersma, Richard H. Duerr, Christopher G. Mathew, John D. Rioux, Dermot McGovern, Judy H. Cho, Michel Georges, Mark J. Daly, Jeffrey C. Barrett

Bibliographic record

VenueNature · 2017
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsMontreal Heart Institute
FundersNational Institute of Dental and Craniofacial ResearchNational Institute of Allergy and Infectious DiseasesNational Cancer InstituteCanadian Institutes of Health ResearchWalloon excellence in life sciences and biotechnologyExzellenzclusters EntzündungsforschungFonds Léon FredericqVetenskapsrådetDeutsche ForschungsgemeinschaftFédération Wallonie-BruxellesCrohn's and Colitis UKFonds De La Recherche Scientifique - FNRSBelgian Federal Science Policy OfficeUniversitetssjukhuset ÖrebroKing's College LondonGénome QuébecEuropean CommissionKennedy Trust for Rheumatology ResearchCrohn's and Colitis FoundationWellcome TrustBundesministerium für Bildung und ForschungNational Institute for Health and Care ResearchNational Institute of Diabetes and Digestive and Kidney DiseasesÖrebro UniversitetMedical Research CouncilLeona M. and Harry B. Helmsley Charitable TrustCrohn's and Colitis Foundation of AmericaGenome CanadaUniversity of Pittsburgh
KeywordsInflammatory bowel diseaseInflammatory Bowel DiseasesResolution (logic)Computational biologyGeneticsBiologyDiseaseMedicineComputer sciencePathologyArtificial intelligence

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.245
Teacher spread0.236 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations644
Published2017
Admission routes2
Has abstractno

Explore more

Same venueNatureSame topicInflammatory Bowel DiseaseFrench-language works237,207