Malignant Ovarian Steroid Cell Tumor Causing Severe Hyperandrogenism: Case Report And Review Of The Literature
Bibliographic record
Abstract
Objective: To report a rare case of malignant ovarian steroid cell tumor with androgen excess.Methods: We describe the clinical presentation and management of a malignant ovarian steroid tumor with severe hyperandrogenism in a postmenopausal woman.Results: An 83-year-old patient had a 6-year history of features of androgen excess. Biochemistry confirmed elevated testosterone and dehydroepiandrosterone sulfate; investigations identified a 4.5-cm adnexal mass that was resected, and the histopathology diagnosis was a malignant steroid cell tumor. Eight months later, disease recurrence prompted a second surgical intervention, and a 3.5-cm mass adherent to the right pelvic sidewall was removed. The patient was not able to tolerate mitotane due to severe side effects. Eighteen months later, the disease relapsed with recurrence of clinical and biochemical features of androgen excess.Conclusion: This case illustrates the challenges of diagnosis and management of malignant ovarian steroid cell tumors.Abbreviations: CT computed tomography; DHEAS dehydroepiandrosterone sulfate; GnRH gonadotropin-releasing hormone; MRI magnetic resonance imaging; SCT steroid cell tumor
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".