Acute Ischemic Stroke Associated With OrthoVisc (Hyaluronic Acid) Injection
Bibliographic record
Abstract
Hyaluronic acid (HA) is one of the main components of normal synovial fluid, acting as a shock absorber and a lubricant in the joints. When injected intra-articularly, the viscosupplementation of HA may potentially restore the biomechanical and biochemical functions of normal synovial fluid and may reduce the pain caused by osteoarthritis through anti-inflammatory, anabolic, analgesic, and chondroprotective mechanisms. HA has been approved by FDA as a medical device and has been used in patients with advanced osteoarthritis. Though it is usually safe and well tolerated, some local and systemic reactions can occur in rare cases. Here we report a 53-year-old man with severe osteoarthritis, who developed acute left cerebellar infarct after the injection of HA (OrthoVisc) preceded by symptoms of allergic reaction. Review of literature showed this is to date the first case of possible link between HA and ischemic stroke. J Med Cases. 2017;8(7):219-223 doi: https://doi.org/10.14740/jmc2853w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".