MECHANISMS OF PROTECTION AGAINST HERPES ZOSTER AND POST-HERPETIC NEURALGIA THROUGH VACCINATION
Bibliographic record
Abstract
Herpes zoster (or Shingles) is a painful blistering rash resulting from the reactivation of latent Varicella-zoster virus (VZV), the agent that causes of chickenpox. With the resolution of chickenpox, VZV-specific cytotoxic T lymphocytes (CTL) access the dorsal root ganglion where VZV lives, to keep viral replication in check. VZV-specific CD4+ and CD8+ T cells are believed to play a central role in latency and reactivation of the virus within the dorsal root ganglion. Reactivation of latent VZV is associated with marked inflammation of the sensory ganglion leading to nerve cell damage and pain that often precedes the onset of the dermatomal rash and persists after the rash resolves. The risk of developing zoster the disabling complication of post-herpetic neuralgia (PHN) dramatically increases with age. These observations highlight the importance of designing vaccines to stimulate cell-mediated immunity to prevent reactivation of VZV and protect against zoster and PHN, rather than the usual focus on antibody responses to prevent infection. Vaccines designed to prevent zoster reactivation and PHN present a significant opportunity for vaccine preventable disability in older adults.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".