Compound-specific isotope analysis resolves the dietary origin of docosahexaenoic acid in the mouse brain
Bibliographic record
Abstract
DHA (22:6n-3) is the major n-3 PUFA within the brain, comprising over 10% of total brain FAs (1, 2). The incorporation of DHA into brain phospholipids serves to regulate the function and structural organization of neuronal membranes, as well as acting as a reservoir of substrate for the production of bioactive docosanoids and DHA-derived docosahexaenoyl ethanolamide (3). Several studies have demonstrated DHA and its enzymatically derived mediators to regulate neurogenesis, cell survival, synaptic function, and the resolution of neural inflammation (3-5). Despite the apparent critical role of DHA in these processes, the brain relies on an external supply of DHA, which can be sustained by either the provision of preformed DHA or through hepatic synthesis from -linolenic acid (ALA; 18:3n-3); however, there is still much debate surrounding the ability of ALA to solely sustain optimal tissue levels of DHA ( As such, the study of DHA metabolism within the brain and other tissues is an area of ongoing research.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.021 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.003 | 0.000 |
| Research integrity | 0.000 | 0.003 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".