Effects of Antrodia Camphorata Mycelia Extract Containing Antroquinonol on Lowering Low-Density Lipoprotein Cholesterol: A Randomized Double-Blind Study
Bibliographic record
Abstract
Objective: Antrodia camphorata is a type of true fungus that grows only on Cinnamomum camphora trees, also known as Cinnamomum kanehirae (“kashi”) in Taiwan. Antroquinonol is a characteristic component of A. camphorata mycelia extract and was previously shown to exhibit antitumor action and lower blood cholesterol (total cholesterol and low-density lipoprotein [LDL] cholesterol) in cellular and animal models. So, This study examined the ability of A. camphorata mycelia extract to reduce LDL cholesterol in humans. Methods: We conducted a randomized double-blind trial in 26 subjects with either borderline LDL cholesterol (120–139 mg/dL; n = 11) or mildly elevated LDL cholesterol (140–159 mg/dL; n = 15). Participants ingested tablets containing either 25 mg of A. camphorata mycelia extract (antroquinonol: 0.68 mg; n = 14) or a placebo (n = 12) for 12 weeks. Results: The test group showed a significant reduction in LDL cholesterol when compared with the placebo group after 12 weeks of tablet ingestion (p < 0.05), demonstrating the effects of A. camphorata mycelia extract on LDL cholesterol. A. camphorata mycelia extract also tended to reduce total cholesterol when compared with the placebo (p < 0.10). The borderline LDL cholesterol and mildly elevated LDL cholesterol subgroups showed a significant reduction in LDL cholesterol in subjects who ingested A. camphorata mycelia extract compared with those who ingested the placebo, again demonstrating the LDL cholesterol-lowering effect of the extract. Conclusion: A. camphorata mycelia extract lowers LDL cholesterol in individuals with somewhat high LDL cholesterol levels. This clinical trial was registered with the University Hospital Medical Information Network (UMIN no. # 000019670).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".