The Neuroimmune Biology of Phagocytosis
Bibliographic record
Abstract
Neutrophil granulocytes, mononuclear-macrophages, dendritic cells, astrocytes and microglia are the phagocyte cells of the innate immune system. These cells recognize self-antigens via receptors for Major Histocompatibility Antigens. Everything what is foreign or denatured material they will ingest and digest. Macrophages, dendritic cells, astrocytes and microglia are antigen presenting cells and thus initiate an antibody and/or cell-mediated immune responses (ADIM). Although they have developed a high degree of autonomy, they interact with the several organ systems, mainly with the nervous and endocrine system with which it is closely and functionally linked. Here we review the neuroimmune biology of the phagocytes emphasizing in the interactions between receptors, cytokines, neurotransmitters and hormones that affect the phagocytic activity. The paper included in this review illustrates that the hormones of the anterior pituitary lobe and posterior lobe plays a differential regulation of the phagocytic activity of macrophages.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".