Abstract WP145: Intra-arterial Stem Cell Therapy for a Persistent Vegetative State Patient: A DTI Analysis of Recovery
Bibliographic record
Abstract
Background: Cell therapy is promising in pre-clinical studies of global ischemia. The aim of this pilot study is to describe the first intra-arterial (IA) delivery of bone marrow derived ALD-401 cells in a persistent vegetative state (PVS) patient in the U.S. & findings on MRI Diffusion Tensor Imaging (DTI) and Diffusion Tensor Tractography (DTT). Material: A 51-yr. woman developed PVS due to cardiac arrest. At 2 years post PVS state, experimental cell therapy was requested by the family. The FDA approved a one-time compassionate use IA delivery of ALD-401 cells. Bone marrow harvest from the patient, followed by processing with flow cytometry was completed to separate ALD-401 cells. Intra-arterial infusion of cells was done bilaterally into each supra-clinoid carotid. Post-infusion neurological assessments- National Institute of Health Stroke Scale (NIHSS), JFKr coma recovery scale, brainstem reflexes, modified Rankin Scores (mRS) and MRI DTI imaging were collected at 1-, 3-, 6-, 9-mo & 1 year Result: The patient had no adverse events peri-operatively. Over 1-year follow-up the patient had 1 hospitalization for UTI and postmenopausal bleeding. No other adverse events occurred. Minor clinical improvement was shown on assessment scales above. However, DTI-DTT analysis of Fractional Anisotropy (FA) showed improvement in the FA and ADC of white matter tracts starting 7 months post injection for the Cortical Spinal Tract (CST) and starting 4 months post injection for the Corpus Callosum (CC) months (see figure). Diffusion Tensor Tractography also showed qualitative improvement in organization and caliber of CC & CST over follow-up post intervention (see figure) Conclusion: Assessing minor neurological improvements in this severe PVS patient remains challenging; DTI-DTT MRI imaging detects changes in white mater tracts that could serve as biomarkers for recovery. Further follow-up clinical assessments and imaging will continue in this patient to define further recovery.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".