IL-4–secreting eosinophils promote endometrial stromal cell proliferation and prevent <i>Chlamydia</i> -induced upper genital tract damage
Bibliographic record
Abstract
Significance Chlamydia trachomatis is the most common sexually transmitted bacterium, but most genital infections in women are asymptomatic. Consistent with this presentation, Chlamydia ascension into human endometrial tissue elicits robust innate and adaptive type 2 immunity. Herein, we genitally infected mice with C. trachomatis to explore the significance of type 2 innate immunity, finding that IL-4–secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia infection from triggering upper genital tract tissue destruction. Such results identify eosinophils as essential for repairing murine genital tissue repair after infectious insult. They also identify a need to define roles played by eosinophils in genital infections of women, and their role in other events associated with endometrial repair, including menstruation, endometritis, and endometriosis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".