MétaCan
Menu
Back to cohort
Record W2751347160 · doi:10.1111/trf.14309

From cytokines to pragmatic designs: changing paradigms

2017· article· en· W2751347160 on OpenAlexafffund
Nancy M. Heddle

Bibliographic record

VenueTransfusion · 2017
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBlood disorders and treatments
Canadian institutionsMcMaster University
FundersCanadian Institutes of Health ResearchCanadian Blood Services
KeywordsHonorHarmMedicineSet (abstract data type)Randomized controlled trialMedical researchPsychologyComputer sciencePathologyInternet privacySocial psychology

Abstract

fetched live from OpenAlex

Emily Cooley was a well-respected medical technologist and morphologist with a remarkable skill set. She was highly regarded both professionally and personally. The "Emily Cooley Lectureship and Award" was established to honor her in particular and medical technologists in general. This article first reviews how a medical laboratory technologist was inspired to become a clinical researcher, then goes on to describe research that led to the discovery of cytokines as the cause of febrile nonhemolytic transfusion and the use of a pragmatic randomized controlled trial design to address evidence of harm when stored red blood cells were transfused. Important lessons for performing quality, meaningful research are highlighted.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.546
metaresearch head score (Gemma)0.658
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.546
Threshold uncertainty score0.560

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.5460.658
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0060.004
Bibliometrics0.0060.004
Science and technology studies0.0030.035
Scholarly communication0.0110.018
Open science0.0070.009
Research integrity0.0090.018
Insufficient payload (model declined to judge)0.0080.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.272
Teacher spread0.255 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designTheoretical or conceptual
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2017
Admission routes2
Has abstractyes

Explore more

Same venueTransfusionSame topicBlood disorders and treatmentsFrench-language works237,207