Increasing dietary salt intake alone does not affect chronic levels of renal sympathetic activity or the responses to stressful stimuli in the rabbit
Bibliographic record
Abstract
The importance of dietary salt in the development of hypertension has long been a source of controversy. Recent studies have suggested the combination of high salt and angiotensin II infusion may be increasing sympathetic drive, however, the effect of a change in dietary salt alone is unclear. We have used telemetry to chronically record renal sympathetic nervous activity (RSNA), arterial pressure (MAP) and heart rate (HR) in 7 New Zealand White rabbits for either 10 days of normal salt diet (0.6g/kg/day NaCl; control) or 5 days prior to and following an increase in salt intake (3g/kg/day; SALT). MAP, HR and RSNA in the SALT group were not significantly different from control either during the baseline period (83±7 mmHg; 240±9bpm; 11±2n.u.) or during high salt (87±9mmHg; 228±9bpm; 12±2n.u.). The responses to common stressful stimuli were also recorded in both groups of animals. Compared to at rest in home cage, being contained in a box, being handled and nasopharyngeal stimulation caused graded increases in MAP (81±4mmHg; 103±6mmHg; 110±5mmHg; 133±8mmHg respectively), HR (223±16bpm; 241±22bpm; 240±17bpm; 29±6bpm) and RSNA (6.4±1nu; 9.6±2nu; 26.2±6nu; 100nu). Stress responses in SALT animals were similar to control. We conclude that a high salt diet alone does not impact on chronic sympathetic drive or the acute responsiveness to stress in rabbits. Supported by the New Zealand Health Research Council.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".