The relationship between transforming growth factor-β with erythema nodosum leprosum recurring events based on immunoglobulin-m anti phenolic glycolipid-1 and cortisol
Bibliographic record
Abstract
ABSTRACT Objective To examine the relationship between transforming growth factor (TGF)-β with recurrent erythema nodosum leprosum (ENL) based on the anti-phenolic glycolipid (PGL)-1 IgM antibody and cortisol in leprosy patients. Methods This research included 44 patients of leprosy MB type; 22 leprosy patients with recurrent ENL reactions as subjects and 22 patients with nonrecurring reaction as controls. We examined the serum levels of TGF-β by ELISA using Human TGF-β Bio legend kit (USA), anti-PGL-1 IgM antibody with the Laboratory of Leprosy Institute of Tropical Disease kit, Airlangga University Surabaya, and cortisol using Stress Xpress Cortisol EIA kit (StressMarq Canada). Results There were 22 subjects with recurrent ENL reaction (16 male, 6 female, mean age 34.9 year). Mean TGF-β was 62.6 ± 30.4 pg/ml, the IgM anti PGL-1 was 2029 ±1687 µg/ml, and the cortisol was 6.61 ± 1.99 µg/dl, and 22 subjects nonrecurring reaction as controls (15 male, 7 female, mean age 47 year) the mean of TGF-β level was 47.2 ± 23 pg/ml, anti PGL-1 IgM antibody was 629 ±1043 µg/ml and the cortisol was 5.07 ± 2.01 µg/dl. The t-independent statistic test the influence of leprosy MB type group to the recurrent ENL reaction and the un-recurrent ENL patients to TGF-β, IgM anti-PGL-1 and cortisol had p value = 0.015, 0.001 and 0.035 ( p <0.05), respectively implying significant difference between subjects and controls. The result of logistic binary test of TGF-β, IgM anti-PGL-1 and cortisol was 0.25, 0.016 and 0.771. This means that IgM anti-PGL-1 has correlation as variable of TGF-β with recurrent ENL. Conclusion There was significant difference between the levels of TGF-β, anti-PGL-1 IgM antibody and cortisol in leprosy patients with the recurrent ENL reaction and those with nonrecurring ENL reaction. There was a correlation between the levels of TGF-β with recurrent ENL based on the IgM anti-PGL-1. The increasing levels of TGF-β and IgM anti-PGL-1 level on patients with leprosy MB type can be a predictor of the recurrent reaction.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".