Bibliographic record
Abstract
The regulation of cardiac homeostasis is especially important in a non-regenerative cell type like the cardiomyocyte. Suppression of hypertrophic and apoptotic signaling pathways is of critical importance for the regulation of cardiac homeostasis. The ubiquitin-proteasomal system is a highly conserved cascade which plays an essential role in regulating a diversity of systems through the rapid post-translational protein modification leading to changes in protein signaling and stability. This system is also important in the cardiovascular system, and in particular, in the heart. In this review, we discuss what is known of the regulation of cardiac homeostasis by the E3 ubiquitin ligase Mule, who’s substrates include the highly characterized proteins p53, myc, and Mcl-1, which are known to play important roles in the regulation of apoptosis and cardiac hypertrophy in heart failure. Mule is also known to play various roles in the regulation of chromatin dynamics, especially following the detection of DNA double strand breaks, and the activation of the DNA damage response. Accordingly, Mule appears to play an indispensable role in the regulation of cardiac homeostasis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".