Proteinase‐activated receptor‐2 blockade inhibits changes seen in a chronic murine asthma model
Bibliographic record
Abstract
Abstract Background Proteinase‐Activated Receptor‐2 ( PAR 2 ) is a G protein‐coupled receptor activated by serine proteinases. We have shown that PAR 2 activation in the airways is involved in the development of allergic inflammation and airway hyperresponsiveness ( AHR ) in acute murine models. We hypothesized that functional inhibition of PAR 2 prevents allergic inflammation, AHR and airway remodeling in chronic allergic airway inflammation models. Material and Methods We developed and used a 12 week model of cockroach extract ( CE )‐mediated AHR , airway inflammation and remodeling in BALB /c mice. Results Mice sensitized and challenged with CE for 12 weeks exhibit AHR , increased numbers of eosinophils in bronchoalveolar lavage ( BAL ) and increased collagen content in the lung tissue compared to saline controls. Administration of an anti‐ PAR 2 antibody, SAM ‐11, after the initial development of airway inflammation significantly inhibited all these parameters. Conclusions Our data demonstrate that PAR 2 signaling plays a key role in CE ‐induced AHR and airway inflammation/remodeling in long term models of allergic airway inflammation. Targeting PAR 2 activation may be a successful therapeutic strategy for allergic asthma.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".