Visible Light Driven Coupling of 2‐aminopyridines and α‐Keto Vinyl Azides for the Synthesis of Imidazo[1, 2‐ <i>a</i> ]pyridines and Their Cytotoxicity
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract α‐Keto vinyl azides and 2‐aminopyridines were coupled to yield 1‐aryl‐ N‐( 2‐arylimidazo[1, 2‐a]pyridin‐3‐yl)methanimines in the presence of visible light using Ru(bpy) 3 Cl 2 .6H 2 O as a photocatalyst. This synthetic protocol allows the formation of 3 new C−N bonds in the overall transformation at ambient temperature. It is applicable to a wide range of vinyl azides and 2‐aminopyridines providing a straightforward access to a variety of highly functionalized imidazo[1, 2‐a]pyridines in high yields. The synthesized imidazo[1, 2‐a]pyridines were evaluated for their cytotoxic activity against a set of four selected human cancer cell lines i.e, A549 (lung cancer), DU‐145 (prostate cancer), MCF‐7 (breast cancer) and Hela (cervical cancer). Many compounds of the series ( 4 e , 4 g , 4 i , 4 j and 4 u ) exhibited promising cytotoxicity in these cancer cell lines.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it