Annulation of 4‐Hydroxypyrones and α‐Keto Vinyl Azides; A Regiospecific Approach towards the Synthesis of Furo[3, 2‐c]Pyrone Scaffolds under Catalyst Free Condition
Bibliographic record
Abstract
Abstract A mild and efficient strategy for the construction of furo[3, 2‐ c ]pyrones via an annulation of α‐keto vinyl azides and 4‐hydroxypyrones under catalyst free condition has been described. Several furo[3, 2‐ c ]pyrone scaffolds were synthesized from readily available vinyl azides and 4‐hydroxypyrones in a regiospecific manner. This protocol allows the formation of new C−O and C−C bonds in a single step to provide a wide variety of substituted furano heterocycles. It is worth noting that the present protocol has several advantages over the conventional methods such as catalyst free, short reaction duration and operational simplicity with good yields.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".