Case report of cerebral phaeohyphomycosis caused by <i>Fonsecaea monophora</i>
Bibliographic record
Abstract
Cerebral phaeohyphomycosis (CP) is a rare cause of fungal central nervous system (CNS) infection. Among the many fungal genera associated with CP, Fonsecaea is rarely the culprit pathogen. As such, Fonsecaea-associated CP is poorly understood, with few cases reported in the literature. The authors report a case of a progressive brain abscess caused by F. monophora in a 63-year-old man with poorly controlled type 2 diabetes, liver cirrhosis, and recent travel to South Sudan. The patient presented with headache and constitutional symptoms 2 days after returning from South Sudan. Fungal culture of a biopsy from a single left frontal abscess isolated a dematiaceous mould that was identified as F. monophora based on colony morphology and DNA sequence analysis of the ribosomal internal transcribed spacer (ITS) region. Despite treatment with liposomal amphotericin B and voriconazole, the patient clinically deteriorated and died. Dematiaceous fungal brain abscesses are a rare cause of CNS infections. Early diagnosis with tissue biopsy is essential for timely access to appropriate antifungal therapy. Complete surgical resection is associated with improved outcomes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.005 | 0.004 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".