197: Neurodevelopmental Status of Children with Macrocephaly and Extraventricular Obstructive Hydrocephalus (EVOH) at Presentation
Bibliographic record
Abstract
EVOH is a relatively common neuroimaging finding in infants and young children who are investigated for macrocephaly. These children typically have non-progressive enlargement of ventricular and extra-axial subarachnoid spaces. Different terms have been used interchangeably many of which include the term “benign”.The association of developmental problems in some of these children begs the question as to whether or not this is indeed a “benign” condition. To study the neurodevelopmental status of children with macrocephaly and EVOH at presentation. A retrospective study of children with macrocephaly and radiologically confirmed EVOH performed by chart review completed by a developmental paediatrician and neuroimaging review by pediatric neuroradiologist. Neurodevelopmental status established by neurodevelopmental examination conducted by pediatric neurologist in the Neurodevelopmental Clinic. 295 patient reports reviewed. 209 reports excluded (93 had clear comorbid neurological, developmental and genetic condition, 73 were multiple reports on a single patient and duplicate entries, 22 were head ultrasound reports only, 13 had no interpretable data, eight had no documented neurodevelopmental clinic visits). 86 children with macrocephaly and EVOH confirmed by head CT and/or MRI were eventually identified. Eighty six children (67 male) with EVOH were identified. Twenty four (28%) had mild to moderate neuro-developmental deficits including: motor (gross and fine), communication, social and adaptive. Most of the children with neurodevelopmental deficits were males (23/24). Preliminary analysis revealed no significant association (P=0.467) between developmental deficits and the degree of ventriculomegaly or extra-axial CSF space enlargement. Nearly one-third of children with macrocephaly and EVOH have mild-moderate deficits, but there appear to be no neuroimaging findings that predict the presence of neurodevelopmental problems. Males with macrocephaly and EVOH appear to be particularly susceptible to developmental problems. EVOH might not necessarily be “benign” in affected children. Children with EVOH merit close neurodevelopmental surveillance in order to institute timely developmental interventions for attainment of as normal a developmental trajectory as possible. The neurobiological mechanisms behind EVOH and the long term neurodevelopmental outcomes with standardized neurodevelopmental testing merits further prospective study.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".