P1485Changes of regional myocardial deformation induced by serelaxin reflect gene regulation in experimental heart failure model
Bibliographic record
Abstract
Background: First animal studies have shown that serelaxin (recombinant human relaxin) has positive effects on cardiovascular remodeling in heart failure. This study aimed to assess whether cardiac magnetic resonance feature tracking (CMR-FT) can detect differences of the effect of serelaxin on myocardial deformation in pressure-overload induced heart failure mice. Also, to assess the relationship between myocardial deformation parameters and histology findings. Methods: Twenty-eight C57BL/6J male, 8–9 week old mice were subjected to SHAM or transverse aortic constriction (TAC) surgery. After 10 weeks TAC-operated mice were randomized into two groups which received either serelaxin 0.5 mg/kg per day (TAC_Srlxn) or sodium acetate (TAC_Veh) administered as a continuous intravenous infusion using Alzet mini pumps for up to 4 weeks. CMR was performed on a 3 T small-animal MRI system (MRS 3017, MR Solutions, Guildford, UK) at week 10 (before start of study treatment) and 14 (end of study treatment) after surgery. The cine images were used to calculate left ventricular (LV) longitudinal (EllLV), circumferential (EccLV) and radial (ErrLV) strain using dedicated software (CMR42, Circle, Calgary, Canada). After the 14th week mice were sacrificed and hearts were harvested for histological analysis. Cross-sections of hearts at the mid-ventricular level were fixed in formalin, embedded in paraffin and stained with Picrosirius red for detection of collagen content.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".