P41 <b>Correlation between analgesics</b>
Bibliographic record
Abstract
<h3>Study Design</h3> Pragmatic randomised controlled trial. <h3>Objectives</h3> To determine the effect of adding analgesics to a standardised rehabilitation program following lateral ankle sprain (LAS) on long-term outcome measures. <h3>Background</h3> Recent guidelines report strong evidence that a short course of certain analgesics may decrease pain and improve function following lateral ankle sprain (LAS). However, reports of swelling and static instability in subjects receiving non-steroidal anti-inflammatories (NSAIDs) following LAS have led to concerns of adverse healing and have been criticised for short-term follow-ups and limited outcome measures. <h3>Methods and Measures</h3> All Canadian Armed Forces (CAF) members reporting to Garrison Petawawa with an acute grade I/II LAS were invited to participate. Eligible subjects were provided a standardised rehabilitation program and randomised to receive either; no medication or a 7 day course of: acetaminophen 500 mg four times/day, celecoxib 100 mg twice/day, or naproxen 500 mg twice/day. In order to determine a statistically significant difference between groups in the Activities of Daily Living subscale of the Foot and Ankle Abilities Measure, using a two-sided significance set at 0.05, a power of 80%, and an estimated attrition rate of 25%, 40 subjects/group were required. Secondary outcome measures included clinical measures of pain, swelling, mobility and instability at 2, 4 and 52 weeks. <h3>Results</h3> To date, 66 subjects have been enrolled and randomised into the; no medication (n=17, 28.3±9.9 years), acetaminophen (n=17, 28.6±7.2 years), celecoxib (n=16, 51.8±14.9 years), or naproxen (n=17, 32.7±10.7 years) groups. All subjects have reported clinically relevant changes in pain and self-reported function between baseline and 3 months, without any differences static instability. Interestingly, only subjects in the no medication or acetaminophen groups have reported clinically relevant changes in swelling. <h3>Conclusion</h3> The preliminary results of this study suggest that the concerns regarding adverse effects on healing and delayed recovery in subjects receiving NSAIDs following LAS may require reconsideration.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".