4: Effect of Phototherapy on the Diagnostic Accuracy of Transcutaneous Bilirubin as Measured by JM103 Device in Preterm Infants
Bibliographic record
Abstract
We have previously shown reliability of transcutaneous bilirubin (TcB) devices for screening preterm infants for hyperbilirubinemia. Few studies have evaluated the validity of TcB in preterm infants following initiation of phototherapy using devices currently available in practice. To compare the accuracy of JM-103 TcB device with total serum bilirubin (TSB) in preterm infants during phototherapy (PT) and post-phototherapy (post-PT) phases. The neonates were included if they met the following criteria: 28-35 weeks of gestation, >24 h and <28 days old and needed total serum bilirubin (TSB) measurement for clinical reasons. TcB was measured at forehead and sternum using JM 103 device when the blood sampling for TSB estimation was conducted. We calculated correlation coefficient statistic and mean bias (TcB-TSB) along with limits of agreement using Bland-Altman plot analysis. A total of 90 preterm infants were enrolled in the study, with mean weight of 1847 g (SD 488) and mean GA 32.4 weeks (SD 1.89), providing comparisons during pre-PT, PT and post-PT phases. The main results are presented below in Table 1 and Table 2. The results show that TcB underestimated TSB both during PT and post-PT phases; however, the bias and precision significantly improved during the post-PT phase. During phototherapy the correlation of TcB with TSB was poor, with exposed site (sternum) showing worse results than the covered site (forehead). However, in the post-PT phase, the correlation coefficients were similar for both TcB measurement sites, and equivalent to those in pre-PT phase. TcB is unreliable for estimation of serum bilirubin during phototherapy; however, it is possible to use JM103 device in post-PT phase to reduce blood samplings in preterm infants.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".