P1502Open-label ODYSSEY APPRISE study: interim data from the first 843 participants
Bibliographic record
Abstract
Background: PCSK9 inhibitors have been recommended as an option by the ESC/EAS Task Force in very high-risk subjects with atherosclerotic cardiovascular (CV) disease and those with HeFH with persistent high LDL-C levels despite maximally tolerated statin and ezetimibe therapies. Purpose: ODYSSEY APPRISE (NCT02476006) was the first European-Canadian collaborative study to provide subjects with severe hypercholesterolaemia at very high CV risk access to the PCSK9 inhibitor alirocumab (ALI) prior to commercial availability (study treatment: ≥12 weeks; ≤30 months) and to assess ALI safety and tolerability. Methods: APPRISE was an open-label, single-arm study, conducted in a real-life setting in 16 European countries and Canada. The study population included subjects with inadequately controlled lipid levels, despite maximally tolerated statins with or without additional lipid-lowering therapies, excluding PCSK9 inhibitors. Based on physician's judgement, participants received either ALI 75 or 150 mg every 2 weeks (Q2W). Study endpoints included efficacy at Week (W)12 and safety.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.013 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.006 | 0.001 |
| Scholarly communication | 0.003 | 0.001 |
| Open science | 0.007 | 0.003 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".