Bibliographic record
Abstract
Many adult mammals and birds respond to heat with thermal tachypnea, an increase in breathing frequency with shallow tidal volume, with minimal increase in oxygen consumption (V̇O2). This pattern favors heat dissipation by evaporative water loss (EWL) through the respiratory tract. We asked to what extent this response was apparent at the earliest stages of development, when pulmonary ventilation (V̇E) initiates. Measurements of V̇E(barometric technique), V̇O2(open-flow methodology) and EWL (water scrubbers) were performed on chicken embryos at the earliest appearance of V̇E, during the internal pipping stage. Data were collected, first, at the normal incubation temperature (37.5°C); then, ambient and egg temperatures were increased to approximately 44°C over a 2 h period. Other embryos of the same developmental stage (controls) were maintained in normothermia for the whole duration of the experiment. During heat exposure, the embryo's V̇O2 and carbon dioxide production increased little. In contrast, V̇E more than doubled (∼128% increase) entirely because of the large rise in breathing frequency (∼132% increase), with no change in tidal volume. EWL did not change significantly, probably because within the egg the thermal and water vapor gradients are almost non-existent. We conclude that chicken embryos respond to a major heat load with tachypnea, like many adult mammals and birds do. The appearance so early in development, although ineffective for heat loss, signifies that thermal tachypnea represents an important breathing response necessary to be functional since hatching.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".