Synthesis of Novel Bis‐Triazolyl Glycoconjugates via Dual Click Reaction for the Selective Recognition of Cu(II) Ions
Bibliographic record
Abstract
Abstract Glycosyl‐β‐azidoester, obtained from corresponding olefinic ester via one‐pot tandem Michael‐diazotransfer reaction, on click coupling with di‐O‐propargylated ethers afforded high yields of novel bis‐triazolyl glycoconjugates. The resulting two distinct class of bis‐triazolyl glycoconjugates includes the bidentate 3‐O‐protected‐α‐D‐glucofuranose bearing two triazolyl glycosylated‐β‐triazoloester groups at 5,6‐positions of sugar scaffold and 1,4:3,6‐dianhydro‐D‐mannitol‐based bidentate glycoconjugate with two triazole groups at 2,5 position of sugar scaffold ( S1 ), and all the triazolyl glycoconjugates been characterization using standard spectral analysis. One of the developed bis‐triazolyl glycoconjugate 7 a has sucessfully been explored as a promissing sensor for the selective recognition of Cu 2+ ions. The probe S1 displayed moderate selective detection of Cu 2+ ions by means of ultraviolet spectroscopy. The Job plot experiment suggested 1:1 complexation of probe S1 (compound 7 a ) with Cu 2+ ions having a detection limit of 8.00 μM.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".